Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction

Semin Dial. 2012 Jan-Feb;25(1):65-73. doi: 10.1111/j.1525-139X.2011.00967.x. Epub 2011 Sep 15.

Abstract

The major cause of hemodialysis vascular access failure is venous stenosis resulting from neointimal hyperplasia. Genetic factors have been shown to be associated with cardiovascular disease and peripheral vascular disease (PVD) in the general population. Genetic factors may also play an important role in vascular access stenosis and development of neointimal hyperplasia by affecting pathways that lead to inflammation, endothelial function, oxidative stress, and vascular smooth muscle proliferation. This review will discuss the role of genetics in understanding neointimal hyperplasia development in hemodialysis vascular access dysfunction and other disease processes with similar neointimal hyperplasia development such as coronary artery disease and PVD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arteriovenous Shunt, Surgical / adverse effects*
  • Arteriovenous Shunt, Surgical / instrumentation
  • Catheters, Indwelling / adverse effects*
  • Equipment Failure
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Hyperplasia / etiology
  • Hyperplasia / genetics
  • Hyperplasia / physiopathology
  • Kidney Failure, Chronic / therapy*
  • Neointima / genetics
  • Neointima / pathology*
  • Oxidative Stress / genetics
  • Peripheral Vascular Diseases / etiology
  • Peripheral Vascular Diseases / genetics*
  • Peripheral Vascular Diseases / pathology
  • Polymorphism, Genetic
  • RNA, Messenger / genetics
  • Renal Dialysis / adverse effects
  • Renal Dialysis / methods*
  • Vascular Diseases

Substances

  • RNA, Messenger