Chromosome 9 ALS and FTD locus is probably derived from a single founder

Neurobiol Aging. 2012 Jan;33(1):209.e3-8. doi: 10.1016/j.neurobiolaging.2011.08.005. Epub 2011 Sep 16.

Abstract

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Finland
  • Frontotemporal Dementia / genetics*
  • Genetic Linkage
  • Genome-Wide Association Study*
  • Haplotypes
  • Humans
  • Polymorphism, Single Nucleotide*