Abstract
The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 genes products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Cell Transformation, Neoplastic / drug effects
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Cell Transformation, Neoplastic / pathology
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Chromosome Mapping*
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Cloning, Molecular
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Embryo, Mammalian / cytology
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Embryo, Mammalian / metabolism
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Fibroblast Growth Factor 6
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Fibroblast Growth Factors*
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Fibroblasts / drug effects
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Fibroblasts / physiology
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Gene Expression / physiology
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Humans
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Mice
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Mice, Inbred C3H
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Molecular Sequence Data
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Molecular Structure
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Muscles / cytology
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Muscles / metabolism
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Myocardium / cytology
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Myocardium / metabolism
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins / physiology
Substances
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FGF6 protein, human
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Fgf6 protein, mouse
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Fibroblast Growth Factor 6
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Proto-Oncogene Proteins
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Fibroblast Growth Factors
Associated data
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GENBANK/X51552
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GENBANK/X51553
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GENBANK/X51554