Abstract
Changing the mechanical properties of the microbubble shell in response to a biochemical stimulus leads to vast changes in both ultrasound-induced bubble dynamics and contrast-enhanced ultrasound imaging. Here, DNA-coated microbubbles are shown to be a simple and highly versatile platform that can silence and re-activate contrast activity in response to the introduction and removal of biochemical stimuli.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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1,2-Dipalmitoylphosphatidylcholine / chemistry
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Acrylic Resins / chemistry
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DNA / chemistry*
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Light
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Microbubbles*
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Oligonucleotides / chemistry
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Phenylpropionates / chemistry
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Phosphatidylethanolamines / chemistry
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Scattering, Radiation
Substances
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3-(2,4-dihydroxyphenyl)propionic acid
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Acrylic Resins
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Oligonucleotides
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Phenylpropionates
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Phosphatidylethanolamines
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1,2-distearoylphosphatidylethanolamine
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1,2-Dipalmitoylphosphatidylcholine
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carbopol 940
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DNA