Multifunctional Giant Amphiphiles via simultaneous copper(I)-catalyzed azide-alkyne cycloaddition and living radical polymerization

Chem Commun (Camb). 2012 Feb 1;48(10):1586-8. doi: 10.1039/c1cc15075h. Epub 2011 Sep 29.

Abstract

A novel class of chemically addressable, multifunctional Giant Amphiphiles was synthesized in excellent yields and polydispersity following simultaneous or sequential living radical polymerization and the click, copper(I)-catalysed azide-alkyne cycloaddition (CuAAC). This new approach allows chemical tailoring of the biomacromolecules and in situ formation of nanocontainers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Animals
  • Azides / chemistry*
  • Catalysis
  • Cattle
  • Click Chemistry
  • Copper / chemistry*
  • Cyclization
  • Hydrophobic and Hydrophilic Interactions
  • Models, Molecular
  • Molecular Structure
  • Polymers / chemistry*
  • Serum Albumin, Bovine / chemistry*

Substances

  • Alkynes
  • Azides
  • Polymers
  • Serum Albumin, Bovine
  • Copper