Brain metastasis of Wilms tumor with diffuse anaplasia and complex cytogenetic phenotype in a child with neurofibromatosis Type 1

J Neurosurg Pediatr. 2011 Oct;8(4):353-6. doi: 10.3171/2011.7.PEDS1119.

Abstract

The authors report the first case of a Wilms tumor (WT) with diffuse anaplasia metastatic to the brain in a 13-year-old girl with a history of neurofibromatosis Type 1. At presentation, the metastatic tumor had radiological features that suggested a meningioma. Histologically it was characterized by striking anaplasia and features similar to the patient's previously resected WT with diffuse anaplasia.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anaplasia / genetics
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Astrocytoma / diagnosis
  • Astrocytoma / therapy
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Craniotomy
  • Female
  • Humans
  • Hypothalamic Neoplasms / diagnosis
  • Hypothalamic Neoplasms / therapy
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / therapy
  • Magnetic Resonance Imaging / methods
  • Nephrectomy*
  • Neurofibromatosis 1 / complications*
  • Neurofibromatosis 1 / genetics
  • Neurosurgical Procedures / methods
  • Phenotype
  • Temporal Lobe / pathology
  • Temporal Lobe / surgery
  • Wilms Tumor / genetics
  • Wilms Tumor / secondary*
  • Wilms Tumor / therapy