Canarene: a triterpenoid with a unique carbon skeleton from Canarium schweinfurthii

Ramsay S T Kamdem; Pascal Wafo; Sammer Yousuf; Zulfiqar Ali; Achyut Adhikari; Saima Rasheed; Ikhlas A Khan; Bonaventure T Ngadjui; Hoong-Kun Fun; M Iqbal Choudhary

doi:10.1021/ol202217d

Canarene: a triterpenoid with a unique carbon skeleton from Canarium schweinfurthii

Org Lett. 2011 Oct 21;13(20):5492-5. doi: 10.1021/ol202217d. Epub 2011 Sep 30.

Authors

Ramsay S T Kamdem¹, Pascal Wafo, Sammer Yousuf, Zulfiqar Ali, Achyut Adhikari, Saima Rasheed, Ikhlas A Khan, Bonaventure T Ngadjui, Hoong-Kun Fun, M Iqbal Choudhary

Affiliation

¹ Department of Organic Chemistry, Higher Teachers' Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon.

PMID: 21961989
DOI: 10.1021/ol202217d

Abstract

Canarene (1), a triterpene with an unprecedented carbon backbone, was isolated from Canarium schweinfurthii . It is the first member of a new class of triterpenoids, for which the name "canarane'' is proposed. 1 showed weak α-glucosidase inhibitory activity, and its structure was unambiguously deduced by single-crystal X-ray diffraction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

1-Deoxynojirimycin / pharmacology
Burseraceae / chemistry*
Cameroon
Crystallography, X-Ray
Dose-Response Relationship, Drug
Glycoside Hydrolase Inhibitors
Molecular Structure
Triterpenes / chemistry*
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Glycoside Hydrolase Inhibitors
Triterpenes
canarene
1-Deoxynojirimycin