Splicing up pluripotency

Brenton R Graveley

doi:10.1016/j.cell.2011.09.004

Splicing up pluripotency

Cell. 2011 Sep 30;147(1):22-4. doi: 10.1016/j.cell.2011.09.004.

Author

Brenton R Graveley¹

Affiliation

¹ Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, Farmington, CT 06030, USA. [email protected]

PMID: 21962502
DOI: 10.1016/j.cell.2011.09.004

Abstract

In this issue of Cell, Gabut and colleagues (2011) identify a new splice variant of FOXP1 that directly regulates the expression of pluripotency genes. It endows human embryonic stem cells with their pluripotent nature and is required for the reprogramming of somatic cells to induced pluripotent stem cells.

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