Abstract
Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Aspergillus niger / drug effects
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Asteraceae / chemistry*
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Candida albicans / drug effects
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Cell Proliferation / drug effects
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Cryptococcus neoformans / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Inositol / chemistry
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Inositol / isolation & purification
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Inositol / pharmacology*
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Staphylococcus aureus / drug effects
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Trichophyton / drug effects
Substances
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Anti-Infective Agents
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Lactones
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Sesquiterpenes
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Inositol