Dendritic cell dysfunction during primary HIV-1 infection

J Infect Dis. 2011 Nov 15;204(10):1557-62. doi: 10.1093/infdis/jir616. Epub 2011 Oct 3.

Abstract

Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and was associated with a distinct surface expression profile of immunomodulatory dendritic cell receptors from the leukocyte immunoglobulin-like receptor family. These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigen Presentation
  • Cross-Sectional Studies
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Female
  • HIV Infections / immunology*
  • HIV-1 / immunology*
  • Humans
  • Immunity, Cellular
  • Interleukin-12 / metabolism
  • Male
  • Middle Aged
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Tumor Necrosis Factor-alpha
  • Interleukin-12