Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6884-7. doi: 10.1016/j.bmcl.2011.09.021. Epub 2011 Sep 17.

Abstract

Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Macrophages / drug effects
  • Macrophages / immunology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Myristica / chemistry*
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / immunology
  • Phenols / chemistry*
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Seeds / chemistry

Substances

  • Anti-Inflammatory Agents
  • Phenols
  • Nitric Oxide