Antibacterial activity of methyl aminolevulinate photodynamic therapy in the treatment of a cutaneous ulcer

Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):793-5. doi: 10.1177/039463201102400326.

Abstract

We describe a 79-year-old female with a chronic venous ulceration infected by Staphylococcus aureus and Enterococcus faecalis and not responsive to conventional treatments. The patient was treated with Methyl-Aminolaevulinate Photodynamic Therapy (MAL-PDT). After four weeks the cutaneous swabs become negative and we observed a significant clinical improvement. Therefore we suppose that MALPDT could represent a valid therapeutic option in the treatment of infected chronic ulcers.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Administration, Topical
  • Aged
  • Aminolevulinic Acid / adverse effects
  • Aminolevulinic Acid / analogs & derivatives*
  • Aminolevulinic Acid / therapeutic use
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Female
  • Humans
  • Photochemotherapy* / adverse effects
  • Photosensitizing Agents / adverse effects
  • Photosensitizing Agents / therapeutic use*
  • Skin / microbiology
  • Skin / pathology
  • Skin Ulcer / drug therapy*
  • Skin Ulcer / microbiology*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Photosensitizing Agents
  • methyl 5-aminolevulinate
  • Aminolevulinic Acid