Abstract
In ICESp2905, a widespread erm(TR)- and tet(O)-carrying genetic element of Streptococcus pyogenes, the two resistance determinants are contained in separate fragments inserted into a scaffold of clostridial origin. ICESp2905 (∼65.6 kb) was transferable not only in its regular form but also in a defective form lacking the erm(TR) fragment (ICESp2906, ∼53.0 kb). The erm(TR) fragment was also an independent integrative and conjugative element (ICE) (ICESp2907, ∼12.6 kb). ICESp2905 thus results from one ICE (ICESp2907) being integrated into another (ICESp2906).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Base Sequence
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Chromosome Mapping
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Chromosomes, Bacterial
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Conjugation, Genetic
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DNA, Bacterial
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DNA, Circular
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Erythromycin / administration & dosage*
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Genes, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Open Reading Frames
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Sequence Analysis, DNA
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Streptococcal Infections / drug therapy*
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Streptococcal Infections / microbiology
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Streptococcal Infections / transmission
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Streptococcus pyogenes / drug effects
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Streptococcus pyogenes / genetics*
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Streptococcus pyogenes / pathogenicity
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Tetracycline / administration & dosage*
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Tetracycline Resistance*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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DNA, Circular
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Erythromycin
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Tetracycline