Abstract
Cell-based therapies for wound repair are limited by inefficient delivery systems that fail to protect cells from the acute inflammatory environment. Here, a biomimetic hydrogel system is described that is based on the polymer pullulan, a carbohydrate glucan known to exhibit potent antioxidant capabilities. It is shown that pullulan hydrogels are an effective cell delivery system and improve mesenchymal stem cell survival and engraftment in high-oxidative-stress environments. The results suggest that glucan hydrogel systems may prove beneficial for progenitor-cell-based approaches to skin regeneration.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / metabolism*
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Antioxidants / pharmacology
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / metabolism
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Biocompatible Materials / pharmacology
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Biomimetics / methods*
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Female
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Glucans / chemical synthesis
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Glucans / metabolism*
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Glucans / pharmacology
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Hydrogels / chemical synthesis
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Hydrogels / metabolism*
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Hydrogen Peroxide / adverse effects
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Hydrogen Peroxide / pharmacology
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Magnetic Resonance Spectroscopy
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Mesenchymal Stem Cells
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Mice
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Mice, Inbred Strains
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Oxidative Stress / drug effects
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Reactive Oxygen Species / antagonists & inhibitors
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Reactive Oxygen Species / metabolism
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Regeneration / drug effects
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Soft Tissue Injuries* / metabolism
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Soft Tissue Injuries* / therapy
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Wound Healing / drug effects
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Wound Healing / physiology*
Substances
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Antioxidants
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Biocompatible Materials
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Glucans
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Hydrogels
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Reactive Oxygen Species
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pullulan
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Hydrogen Peroxide