Efficacy and safety of acute injection laryngoplasty for vocal cord paralysis following thoracic surgery

Laryngoscope. 2011 Nov;121(11):2406-10. doi: 10.1002/lary.22178. Epub 2011 Oct 12.

Abstract

Objectives/hypothesis: The primary objective of this study was to evaluate the effectiveness and safety of injection laryngoplasty using a temporary injectable agent in the acute setting for patients with unilateral vocal cord paralysis following thoracic surgical procedures.

Study design: Retrospective consecutive case series in an academic institution.

Methods: Inclusion criteria included patients acutely treated with injection laryngoplasty from January 1, 2006, to March 31, 2010, for a unilateral vocal cord paralysis that occurred after a thoracic surgical procedure (N = 20). All patients were injected with Radiesse Voice Gel using microlaryngoscopy technique.

Results: The mean time to vocal cord injection from the time of thoracic surgery was 4.5 days. There was one operative-related complication of intraoperative bile reflux that caused a pneumonitis. Ninety percent of patients were recommended for strict nothing by mouth prior to injection. Of these, 94% were allowed an oral diet following injection, and 67% tolerated a regular diet. None of the patients required subsequent procedures for aspiration or dysphagia, and 25% required further intervention after discharge for persistent dysphonia. Patients with a known nerve transection had a higher rate of dysphonia requiring further surgical procedures than those who did not have a known nerve transection.

Conclusions: Acute treatment of thoracic surgery-related unilateral vocal cord paralysis with injection laryngoplasty appears safe and effective at preventing postoperative aspiration pneumonia and improves swallowing function to allow resumption of an oral diet. A single injection is often the only required treatment.

MeSH terms

  • Adult
  • Aged
  • Carboxymethylcellulose Sodium / administration & dosage*
  • Esophagectomy / adverse effects
  • Female
  • Humans
  • Injections
  • Laryngoplasty / methods*
  • Male
  • Microsurgery / methods*
  • Middle Aged
  • Pneumonectomy / adverse effects
  • Postoperative Complications / surgery*
  • Retrospective Studies
  • Thoracic Surgical Procedures / adverse effects*
  • Treatment Outcome
  • Vocal Cord Paralysis / surgery*
  • Young Adult

Substances

  • Carboxymethylcellulose Sodium