Xpert MTB/RIF assay for diagnosis of pleural tuberculosis

J Clin Microbiol. 2011 Dec;49(12):4341-2. doi: 10.1128/JCM.05454-11. Epub 2011 Oct 12.

Abstract

We prospectively investigated the diagnostic utility of the Xpert MTB/RIF (Mycobacterium tuberculosis/rifampin [RIF] resistance) assay in 20 cases with confirmed tuberculous pleural effusion. The sensitivity and specificity of the Xpert assay in pleural fluid were 25% and 100%, respectively. All cases positive by the Xpert assay were also positive by pleural fluid culture.

Publication types

  • Evaluation Study

MeSH terms

  • Antitubercular Agents / pharmacology
  • Bacteriological Techniques / methods*
  • Drug Resistance, Bacterial*
  • Humans
  • Molecular Diagnostic Techniques / methods*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Prospective Studies
  • Rifampin / pharmacology
  • Sensitivity and Specificity
  • Tuberculosis, Pleural / diagnosis*
  • Tuberculosis, Pleural / microbiology*

Substances

  • Antitubercular Agents
  • Rifampin