Dietary antioxidants and forced expiratory volume in 1 s decline: the Health, Aging and Body Composition study

Eur Respir J. 2012 Apr;39(4):979-84. doi: 10.1183/09031936.00190010. Epub 2011 Oct 17.

Abstract

Increased antioxidant defences are hypothesised to decrease age- and smoking-related decline in lung function. The relationship between dietary antioxidants, smoking and forced expiratory volume in 1 s (FEV(1)) was investigated in community-dwelling older adults in the Health, Aging and Body Composition study. 1,443 participants completed a food frequency questionnaire, self-reported smoking history and had measurements taken of FEV(1) at both baseline and after 4 yrs of follow-up. The association of dietary intake of nutrients and foods with antioxidant properties and rate of FEV(1) decline was investigated using hierarchical linear regression models. In continuing smokers (current smokers at both time-points), higher vitamin C intake and higher intake of fruit and vegetables were associated with an 18 and 24 mL · yr(-1) slower rate of FEV(1) decline compared with a lower intake (p < 0.0001 and p = 0.003, respectively). In quitters (a current smoker at study baseline who had quit during follow-up), higher intake was associated with an attenuated rate of decline for each nutrient studied (p ≤ 0.003 for all models). In nonsmoking participants, there was little or no association of diet and rate of decline in FEV(1). The intake of nutrients with antioxidant properties may modulate lung function decline in older adults exposed to cigarette smoke.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Aging / physiology*
  • Antioxidants / administration & dosage*
  • Body Composition*
  • Cohort Studies
  • Feeding Behavior
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume*
  • Humans
  • Longitudinal Studies
  • Lung Diseases / diagnosis
  • Lung Diseases / epidemiology*
  • Lung Diseases / metabolism
  • Male
  • Oxidants / administration & dosage
  • Predictive Value of Tests
  • Respiratory Function Tests
  • Smoking / epidemiology*
  • Smoking / metabolism

Substances

  • Antioxidants
  • Oxidants