Epoxides: comparison of the induction of SOS repair in Escherichia coli PQ37 and the bacterial mutagenicity in the Ames test

W von der Hude; A Seelbach; A Basler

doi:10.1016/0027-5107(90)90027-2

Epoxides: comparison of the induction of SOS repair in Escherichia coli PQ37 and the bacterial mutagenicity in the Ames test

Mutat Res. 1990 Aug;231(2):205-18. doi: 10.1016/0027-5107(90)90027-2.

Authors

W von der Hude¹, A Seelbach, A Basler

Affiliation

¹ Institut für Allgemeine Genetik, FU Berlin, Germany.

PMID: 2200956
DOI: 10.1016/0027-5107(90)90027-2

Abstract

The genotoxicity of 51 epoxides is studied with the SOS-Chromotest using Escherichia coli PQ37 as tester strain. The results obtained with this test system are compared with results of the Ames test. Out of 51 epoxides, 39 are shown to be mutagenic in Salmonella typhimurium whereas only 27 mutagenic epoxides induced the SOS response in Escherichia coli PQ37.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

DNA Repair*
Epoxy Compounds / toxicity*
Escherichia coli / genetics*
Ethers, Cyclic / toxicity*
Mutagenicity Tests
Mutation*
SOS Response, Genetics*

Substances

Epoxy Compounds
Ethers, Cyclic