Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects

Small. 2011 Dec 2;7(23):3281-6. doi: 10.1002/smll.201101836. Epub 2011 Oct 19.

Abstract

An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antigen Presentation / drug effects*
  • Antigens / immunology*
  • Biocompatible Materials / pharmacology*
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / drug effects
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects
  • Electrolytes / pharmacology*
  • Immunity, Cellular / drug effects
  • Immunity, Humoral / drug effects
  • Mice
  • Microscopy, Electron, Scanning
  • Microscopy, Fluorescence
  • Nanogels
  • Ovalbumin / immunology
  • Particle Size
  • Polyethylene Glycols / pharmacology*
  • Polyethyleneimine / pharmacology*
  • Static Electricity
  • Vaccines / immunology*

Substances

  • Adjuvants, Immunologic
  • Antigens
  • Biocompatible Materials
  • Electrolytes
  • Nanogels
  • Vaccines
  • polyethylene glycol polyethyleneimine nanogel
  • Polyethylene Glycols
  • Polyethyleneimine
  • Ovalbumin