Abstract
Human enterovirus 71 (EV71) is one of the major etiological agents for the hand, foot, and month disease (HFMD) and is causing frequent, widespread occurrence in the mainland of China. The single positive-stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins. The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication. This article reviews the studies of the structures and functions of nonstructural proteins of EV71 and the anti-enterovirus 71 drugs targeting on these nonstructural proteins.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Antiviral Agents / pharmacology*
-
Enterovirus A, Human / enzymology*
-
Enterovirus A, Human / genetics
-
Enterovirus A, Human / isolation & purification
-
Hand, Foot and Mouth Disease / drug therapy
-
Hand, Foot and Mouth Disease / virology*
-
Humans
-
Molecular Targeted Therapy*
-
Peptide Hydrolases / chemistry*
-
Peptide Hydrolases / metabolism
-
Peptide Hydrolases / physiology
-
Protein Kinase Inhibitors / pharmacology
-
RNA, Viral / genetics
-
Viral Nonstructural Proteins / chemistry*
-
Viral Nonstructural Proteins / metabolism
-
Viral Nonstructural Proteins / physiology
-
Virus Replication / drug effects
Substances
-
Antiviral Agents
-
Protein Kinase Inhibitors
-
RNA, Viral
-
Viral Nonstructural Proteins
-
Peptide Hydrolases