Abstract
We describe the clinical, microbiologic, and molecular features of the first series of qacA/B-containing strains of methicillin-resistant Staphylococcus aureus from infected US patients. All qac-carrying strains were clonally diverse, and qacA strains exhibited increased tolerance to chlorhexidine as measured by minimum inhibitory concentrations, minimum bactericidal concentrations, and postexposure colony counts.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Adult
-
Aged
-
Anti-Infective Agents, Local / pharmacology*
-
Bacterial Proteins / genetics*
-
Chlorhexidine / analogs & derivatives*
-
Chlorhexidine / pharmacology
-
District of Columbia / epidemiology
-
Electrophoresis, Gel, Pulsed-Field
-
Female
-
Hospitals, Community
-
Hospitals, Teaching
-
Humans
-
Male
-
Maryland / epidemiology
-
Membrane Transport Proteins / genetics*
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Methicillin-Resistant Staphylococcus aureus / genetics*
-
Methicillin-Resistant Staphylococcus aureus / isolation & purification
-
Microbial Sensitivity Tests
-
Middle Aged
-
Penicillin-Binding Proteins
-
Real-Time Polymerase Chain Reaction
-
Staphylococcal Infections / epidemiology*
-
Statistics, Nonparametric
-
Virginia / epidemiology
-
Young Adult
Substances
-
Anti-Infective Agents, Local
-
Bacterial Proteins
-
FemA protein, Bacteria
-
Membrane Transport Proteins
-
Penicillin-Binding Proteins
-
QacB protein, Staphylococcus aureus
-
mecA protein, Staphylococcus aureus
-
qacA protein, Staphylococcus aureus
-
chlorhexidine gluconate
-
Chlorhexidine