Abstract
Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting protein kinase 3 (RIPK3), a kinase that triggers an alternative form of cell death called programmed necrosis. Interestingly, these recent findings can be reconciled with earlier work on the non-apoptotic roles of caspase 8.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / physiology
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CASP8 and FADD-Like Apoptosis Regulating Protein / physiology
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Caspase 8 / physiology*
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Cell Death / physiology*
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Cell Survival / physiology*
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Humans
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Inflammation / pathology
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Inflammation / physiopathology
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Models, Biological
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Receptor-Interacting Protein Serine-Threonine Kinases / physiology
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Signal Transduction / physiology
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Tumor Necrosis Factor-alpha / physiology
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Ubiquitination
Substances
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CASP8 and FADD-Like Apoptosis Regulating Protein
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Tumor Necrosis Factor-alpha
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Receptor-Interacting Protein Serine-Threonine Kinases
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Caspase 8