Orienting fate: spatial regulation of neurogenic divisions

Neuron. 2011 Oct 20;72(2):191-3. doi: 10.1016/j.neuron.2011.10.003.

Abstract

Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the output of neural progenitor cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Cell Lineage / physiology*
  • Cell Polarity / physiology*
  • Neocortex / growth & development*
  • Neurogenesis / physiology*
  • Neurons / metabolism*
  • Spindle Apparatus / metabolism*

Substances

  • Cell Cycle Proteins
  • inscuteable protein, mouse