Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Elisa Tassano; Elisa Tavella; Concetta Micalizzi; Francesca Scuderi; Cristina Cuoco; Cristina Morerio

doi:10.1016/j.cancergen.2011.08.015

Monosomal complex karyotype in pediatric mixed phenotype acute leukemia

Cancer Genet. 2011 Sep;204(9):507-11. doi: 10.1016/j.cancergen.2011.08.015.

Authors

Elisa Tassano¹, Elisa Tavella, Concetta Micalizzi, Francesca Scuderi, Cristina Cuoco, Cristina Morerio

Affiliation

¹ Laboratorio di Citogenetica Ematoncologica, Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Giannina Gaslini, Genova, Italy.

PMID: 22018273
DOI: 10.1016/j.cancergen.2011.08.015

Abstract

We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
Comparative Genomic Hybridization
Cytogenetic Analysis
Female
Humans
In Situ Hybridization, Fluorescence
Karyotype
Leukemia, Biphenotypic, Acute / diagnosis
Leukemia, Biphenotypic, Acute / genetics*
Leukemia, Biphenotypic, Acute / pathology