Abstract
Peptide-modified silver nanoparticles have been coated with an erbium-doped silica layer using a method inspired by silica biomineralization. Electron microscopy and small-angle X-ray scattering confirm the presence of an Ag/peptide core and silica shell. The erbium is present as small Er(2)O(3) particles in and on the silica shell. Raman, IR, UV-Vis, and circular dichroism spectroscopies show that the peptide is still present after shell formation and the nanoparticles conserve a chiral plasmon resonance. Magnetic measurements find a paramagnetic behavior. In vitro tests using a macrophage cell line model show that the resulting multicomponent nanoparticles have a low toxicity for macrophages, even on partial dissolution of the silica shell.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomimetic Materials* / chemical synthesis
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Biomimetic Materials* / chemistry
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Biomimetic Materials* / pharmacokinetics
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Biomimetic Materials* / pharmacology
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Cell Line
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Erbium* / chemistry
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Erbium* / pharmacokinetics
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Erbium* / pharmacology
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Humans
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Macrophages / cytology
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Macrophages / metabolism*
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Magnetic Phenomena
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Nanoparticles / chemistry*
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Peptides* / chemistry
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Peptides* / pharmacokinetics
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Peptides* / pharmacology
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Silicon Dioxide* / chemical synthesis
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Silicon Dioxide* / chemistry
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Silicon Dioxide* / pharmacokinetics
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Silicon Dioxide* / pharmacology
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Silver* / chemistry
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Silver* / pharmacokinetics
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Silver* / pharmacology
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Spectrum Analysis
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Surface Plasmon Resonance / methods*
Substances
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Peptides
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Silver
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Silicon Dioxide
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Erbium