Abstract
The synthesis of N-aryl-2-carboxyl-3-hydroxy-5-arylpyrroles has been achieved in high yield by the combination of a TBSO-substituted vinyldiazoacetate and nitrones in a one-pot cascade process involving copper-catalyzed Mannich addition, dirhodium-catalyzed dinitrogen extrusion and N-OTBS insertion, and acid-promoted aromatization (elimination).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Butyric Acid / chemistry*
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Catalysis
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Copper / chemistry
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Hydroxylation
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Models, Molecular
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Molecular Structure
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Nitrogen Oxides / chemistry*
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Pyrroles / chemical synthesis*
Substances
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Nitrogen Oxides
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Pyrroles
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nitrones
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Butyric Acid
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Copper