Abstract
We studied lesions of molluscum contagiosum with a panel of monoclonal antibodies to determine the phenotype of infiltrating cells and antigen modifications of infected keratinocytes. Our data indicate (1) a complete lack of immunocompetent cells in the viral lesions, and simultaneously a loss of B2-microglobulin reactivity by molluscum bodies, a cellular activation of EGF and transferrin receptors and expression of CD36 antigen of these bodies; (2) a moderate infiltrate of activated T cells and monocytes in the underlying epidermis; (3) an increase of Langerhans cell density and a CD36 expression by the surface of upper layer keratinocytes in the perilesional epidermis.
MeSH terms
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Epithelium / immunology
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Epithelium / metabolism
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Epithelium / microbiology
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ErbB Receptors / immunology
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ErbB Receptors / metabolism
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HLA-DR Antigens / immunology
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HLA-DR Antigens / metabolism
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Humans
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Immunohistochemistry
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Keratinocytes / immunology
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Keratinocytes / metabolism
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Keratinocytes / microbiology
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Langerhans Cells / immunology
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Langerhans Cells / metabolism
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Langerhans Cells / microbiology
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Molluscum Contagiosum / immunology
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Molluscum Contagiosum / metabolism
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Molluscum Contagiosum / pathology*
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Receptors, Transferrin / immunology
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Receptors, Transferrin / metabolism
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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T-Lymphocytes / microbiology
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beta 2-Microglobulin / immunology
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beta 2-Microglobulin / metabolism
Substances
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HLA-DR Antigens
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Receptors, Transferrin
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beta 2-Microglobulin
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ErbB Receptors