Abstract
The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.
Copyright © 2011 S. Karger AG, Basel.
MeSH terms
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Epithelial Sodium Channels / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Ion Transport
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Kidney / metabolism*
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Minor Histocompatibility Antigens
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Nephrons / metabolism
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Potassium / metabolism*
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Potassium Channels, Inwardly Rectifying / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Sodium / metabolism*
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Sodium, Dietary / metabolism
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WNK Lysine-Deficient Protein Kinase 1
Substances
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Epithelial Sodium Channels
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Intracellular Signaling Peptides and Proteins
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KCNJ1 protein, human
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Minor Histocompatibility Antigens
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Potassium Channels, Inwardly Rectifying
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Sodium, Dietary
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Sodium
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Protein Serine-Threonine Kinases
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WNK Lysine-Deficient Protein Kinase 1
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WNK1 protein, human
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Potassium