Abstract
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cytokines / metabolism
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Galactosylceramides / administration & dosage
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Galactosylceramides / chemical synthesis*
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Galactosylceramides / chemistry
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Hexuronic Acids / administration & dosage
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Hexuronic Acids / chemical synthesis*
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Hexuronic Acids / chemistry
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Mice
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Molecular Conformation
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Stereoisomerism
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Surface Plasmon Resonance
Substances
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Cytokines
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Galactosylceramides
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Hexuronic Acids
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galacturonic acid
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KRN 7000