Abstract
Cytokines are essential regulators of hematopoesis and the immune system. Genetic engineering of recombinant cytokines has facilitated their implementation in many clinical areas. In the field of oncology the granulopoetic human growth factors G-CSF and GM-CSF are of particular importance. They can be applied to prevent chemotherapy induced neutropenia. Furthermore, they allow for mobilization of hematopoetic stem cells in order to obtain peripheral blood stem cell transplants. Another class of cytokines, the interferons, possess immunomodulating, antiproliferative, and antiviral properties. While the significance of interferon alfa as an antitumor agent is dwindling, it still plays a very important role in the therapy of chronic hepatitis b and c. Interferon beta is successfully used to treat multiple sclerosis. Among the heterogenous group of interleukines in particular interleukin 2 has reached clinical practice as an immunostimulating agent in the therapy of metastatic renal cell carcinoma. Many other cytokines have yet to undergo clinical trials.
MeSH terms
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Adjuvants, Immunologic / adverse effects
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Adjuvants, Immunologic / therapeutic use*
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use
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Carcinoma, Renal Cell / drug therapy
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Carcinoma, Renal Cell / immunology
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Cytokines / adverse effects
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Cytokines / therapeutic use*
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Genetic Engineering
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Granulocyte Colony-Stimulating Factor / adverse effects
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Granulocyte-Macrophage Colony-Stimulating Factor / adverse effects
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Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
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Hematopoietic Stem Cell Mobilization
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Hematopoietic Stem Cell Transplantation
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Humans
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Immunologic Factors / adverse effects
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Immunologic Factors / therapeutic use
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Interferons / adverse effects
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Interferons / therapeutic use
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Kidney Neoplasms / drug therapy
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Kidney Neoplasms / immunology
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Multiple Sclerosis / drug therapy
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Multiple Sclerosis / immunology
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Neoplasms / drug therapy
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Neoplasms / immunology
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Neutropenia / drug therapy
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Neutropenia / immunology
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Recombinant Proteins / adverse effects
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Recombinant Proteins / therapeutic use
Substances
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Adjuvants, Immunologic
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Antineoplastic Agents
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Cytokines
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Immunologic Factors
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor
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Interferons