Abstract
During meiotic recombination in the yeast Saccharomyces cerevisiae, heteroduplexes are formed as an intermediate in the exchange process. In the formation of an asymmetric heteroduplex, one chromosome acts as a donor of a single DNA strand and the other acts as a recipient. We present genetic evidence that the nontranscribed strand is donated more frequently than the transcribed strand in spores that have an unrepaired mismatch at the HIS4 locus.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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DNA Repair
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DNA, Fungal / genetics
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DNA, Fungal / metabolism
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Genes, Fungal
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Histidine / metabolism
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Molecular Sequence Data
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Nucleic Acid Conformation
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Nucleic Acid Heteroduplexes / metabolism
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Recombination, Genetic*
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / physiology
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Spores, Fungal
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Transcription, Genetic*
Substances
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DNA, Fungal
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Nucleic Acid Heteroduplexes
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Histidine