Bioresolution of benzyl glycidyl ether using whole cells of Bacillus alcalophilus

J Basic Microbiol. 2012 Aug;52(4):383-9. doi: 10.1002/jobm.201100204. Epub 2011 Nov 3.

Abstract

The incubation of whole Bacillus alcalophilus cells grown on a mineral supplemented medium (MSM) containing 1% (w/v) sucrose as carbon source, 1.2% (w/v) tryptone as nitrogen source at pH 6.5 and temperature 30 °C in 24 h kinetically resolved benzyl glycidyl ether (1 mg/ml) to provide (S)-benzyl glycidyl ether with 30% ee and (R)-3-benzyloxypropane-1,2-diol with 40% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacillus / metabolism*
  • Biotechnology / methods*
  • Carbon / metabolism
  • Culture Media / chemistry
  • Epoxy Compounds / metabolism*
  • Hydrogen-Ion Concentration
  • Nitrogen / metabolism
  • Peptones / metabolism
  • Sucrose / metabolism
  • Temperature

Substances

  • Culture Media
  • Epoxy Compounds
  • Peptones
  • glycidyl ethers
  • Sucrose
  • tryptones
  • Carbon
  • Nitrogen