Indications and practice with androgen deprivation therapy

The Cancer of the Prostate Strategic Urological Research Endeavor (CaPSURE) is an ongoing longitudinal observational study of current trends in prostate cancer staging and treatment across a spectrum of different treatment facilities in the United States. To date, the study has documented 2 principal findings: (a) a large variation exists in the treatment choices applied to similar patient presentations across the range of facility type, size, and geographic location in the United States; and (b) although it does not seem to make much difference in mortality outcomes which approach--hormonal therapy, radiotherapy, or surgery--is applied to men at low or intermediate risk, a survival benefit exists with surgery for men at high risk.