Abstract
Mixtures of drug-resistant and drug-sensitive tumour cells growing in 3-dimensional boluses in collagen gel matrix are shown to be effectively coupled so that the response of the mixture is significantly influenced by a subpopulation making up only 1% of the total cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aminopterin / pharmacology
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Animals
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Cell Communication / drug effects
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Cell Division / drug effects
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Cells, Cultured
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Collagen / pharmacology
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Dose-Response Relationship, Drug
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Hypoxanthine
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Hypoxanthines / pharmacology
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Mammary Neoplasms, Experimental / metabolism*
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Mice
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Ouabain / pharmacology
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Thioguanine / pharmacology
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Thymidine / pharmacology
Substances
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Hypoxanthines
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Hypoxanthine
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Ouabain
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Collagen
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Thioguanine
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Aminopterin
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Thymidine