Abstract
Acanthopanax koreanum is well known herb in traditional Korean, Chinese, and Japanese anti-inflammatory action without any adverse effects. In the current study, we investigated the inhibitory effects of isolated compounds 1-13 from the leaves of A. koreanum on the lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Of these lupane-type triterpenoids, 1 exhibited particularly high inhibitory effect on lipopolysaccharide-stimulated TNF-α, IL-6, and IL-12 production with the values ranging from 45.0 to 84.5% at a concentration of 50 μM. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Bone Marrow Cells / drug effects
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Cells, Cultured
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Cytokines / biosynthesis
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Dendritic Cells / drug effects*
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Eleutherococcus / chemistry*
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Interleukin-12 / biosynthesis
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Interleukin-6 / biosynthesis
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Lipopolysaccharides / pharmacology*
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Mice
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Mice, Inbred C57BL
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Tetrazolium Salts
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Thiazoles
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Triterpenes / chemistry
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Triterpenes / pharmacology*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Interleukin-6
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Lipopolysaccharides
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Plant Extracts
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Tetrazolium Salts
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Thiazoles
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Triterpenes
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Tumor Necrosis Factor-alpha
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Interleukin-12
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lupane
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thiazolyl blue