New driver for lipid synthesis

Sander M Houten; Carmen A Argmann

doi:10.1016/j.cell.2011.10.019

New driver for lipid synthesis

Cell. 2011 Nov 11;147(4):719-21. doi: 10.1016/j.cell.2011.10.019.

Authors

Sander M Houten¹, Carmen A Argmann

Affiliation

¹ Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. [email protected]

PMID: 22078872
DOI: 10.1016/j.cell.2011.10.019

Abstract

Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. These findings suggest a link between lipid synthesis and cellular pathways involved in methylation.

Publication types

Comment