Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6

Norifumi Shigemoto; Ryuichi Kuwahara; Shizuo Kayama; Wataru Shimizu; Makoto Onodera; Michiya Yokozaki; Junzo Hisatsune; Fuminori Kato; Hiroki Ohge; Motoyuki Sugai

doi:10.1016/j.diagmicrobio.2011.09.019

Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6

Diagn Microbiol Infect Dis. 2012 Jan;72(1):109-12. doi: 10.1016/j.diagmicrobio.2011.09.019. Epub 2011 Nov 10.

Authors

Norifumi Shigemoto¹, Ryuichi Kuwahara, Shizuo Kayama, Wataru Shimizu, Makoto Onodera, Michiya Yokozaki, Junzo Hisatsune, Fuminori Kato, Hiroki Ohge, Motoyuki Sugai

Affiliation

¹ Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan.

PMID: 22078906
DOI: 10.1016/j.diagmicrobio.2011.09.019

Abstract

We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Anti-Bacterial Agents / pharmacology*
Conjugation, Genetic
Female
Gene Transfer, Horizontal
Humans
Imipenem / pharmacology*
Japan
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / genetics
Klebsiella pneumoniae / isolation & purification
Male
Meropenem
Plasmids / analysis
Thienamycins / pharmacology*
beta-Lactam Resistance*
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Thienamycins
Imipenem
beta-Lactamases
Meropenem