Synthesis of biologically active derivatives of D-glucosamine-4-phosphate and 1-thyminyl-D-glucosamine-4,6-disulfate

Chem Pharm Bull (Tokyo). 1990 Jun;38(6):1766-8. doi: 10.1248/cpb.38.1766.

Abstract

New 1-thyminyl-D-glucosamine-4-phosphate and 1-thyminyl-D-glucosamine-4,6-disulfate derivatives were synthesized. The 1-thyminyl-D-glucosamine-4,6-disulfate derivative showed antiviral activity against HIV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Glucosamine / analogs & derivatives*
  • Glucosamine / chemical synthesis
  • Glucosamine / pharmacology
  • Glucosephosphates / chemical synthesis
  • Glucosephosphates / pharmacology*
  • HIV / drug effects*
  • Thymine / analogs & derivatives*
  • Thymine / chemical synthesis
  • Thymine / pharmacology

Substances

  • Antiviral Agents
  • Glucosephosphates
  • glucosamine 4-phosphate
  • 1-thyminylglucosamine-4,6-disulfate
  • Glucosamine
  • Thymine