Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells

M Limonta; A Biondi; G Giudici; G Specchia; C Catapano; G Masera; T Barbui; M D'Incalci

doi:10.1007/BF02897289

Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells

Cancer Chemother Pharmacol. 1990;26(5):340-2. doi: 10.1007/BF02897289.

Authors

M Limonta¹, A Biondi, G Giudici, G Specchia, C Catapano, G Masera, T Barbui, M D'Incalci

Affiliation

¹ Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

PMID: 2208574
DOI: 10.1007/BF02897289

Abstract

4-Demethoxydaunorubicin (4-DMDR) and its major metabolite 4-demethoxy-13-hydroxydaunorubicin (4-DMDRol) were investigated for their cytotoxicity and mode of action against human leukemic cells. The drug and its metabolite appeared to be equally potent as both inhibitors of cell proliferation and inducers of DNA double-strand breaks in the OCI AML-3 cell line and cells derived directly from patients with acute myeloid leukemia (AML). This suggests that 4-DMDRol plays an important role in the antileukemic activity of 4-DMDR.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antineoplastic Agents*
Cell Division / drug effects
DNA Damage*
DNA, Neoplasm / drug effects*
Daunorubicin / analogs & derivatives*
Daunorubicin / pharmacology
Humans
Idarubicin / metabolism
Idarubicin / pharmacology*
Leukemia, Myeloid, Acute / metabolism
Leukemia, Myeloid, Acute / pathology*
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / metabolism
Tumor Cells, Cultured / pathology
Tumor Stem Cell Assay

Substances

Antineoplastic Agents
DNA, Neoplasm
idarubicinol
Idarubicin
Daunorubicin