Abstract
Twelve trachoma-hyperendemic communities were treated with 3 annual mass azithromycin distributions. Children aged 0-9 years were monitored 1 year following the third treatment. An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7).
Trial registration:
ClinicalTrials.gov NCT00322972.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage*
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Antibiotic Prophylaxis / methods
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Azithromycin / administration & dosage*
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Child
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Child, Preschool
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Chlamydia trachomatis / genetics
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Chlamydia trachomatis / isolation & purification*
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Ethiopia / epidemiology
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Female
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Humans
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Infant
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Male
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Prevalence
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Preventive Health Services
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RNA, Bacterial / analysis*
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RNA, Bacterial / genetics
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RNA, Ribosomal / analysis*
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RNA, Ribosomal / genetics
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Statistics, Nonparametric
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Trachoma / drug therapy
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Trachoma / epidemiology
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Trachoma / microbiology
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Trachoma / prevention & control*
Substances
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Anti-Bacterial Agents
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RNA, Bacterial
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RNA, Ribosomal
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Azithromycin
Associated data
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ClinicalTrials.gov/NCT00322972