Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3,4-dichloroisocoumarin

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1378-81. doi: 10.1107/S1744309111032222. Epub 2011 Oct 27.

Abstract

A recombinant lipase (triacylglycerol acylhydrolase; EC 3.1.1.3) from the bacterium Streptomyces rimosus was inhibited by the serine protease inhibitor 3,4-dichloroisocoumarin and crystallized by the hanging-drop vapour-diffusion method at 291 K. The crystals belonged to the monoclinic space group P2(1), with unit-cell parameters a = 38.1, b = 78.7, c = 56.6 Å, β = 104.5° and probably two molecules in the asymmetric unit. Diffraction data were collected to 1.7 Å resolution using synchrotron radiation on the XRD beamline of the Elettra synchrotron, Trieste, Italy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coumarins / chemistry*
  • Crystallization
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemistry*
  • Extracellular Space / enzymology
  • Isocoumarins
  • Lipase / chemistry*
  • Streptomyces / enzymology*

Substances

  • Coumarins
  • Enzyme Inhibitors
  • Isocoumarins
  • 3,4-dichloroisocoumarin
  • Lipase