Cell-autonomous and cell-to-cell signalling events in normal and altered neuronal migration

Eur J Neurosci. 2011 Nov;34(10):1595-608. doi: 10.1111/j.1460-9568.2011.07867.x.

Abstract

The cerebral cortex is a complex six-layered structure that contains an important diversity of neurons, and has rich local and extrinsic connectivity. Among the mechanisms governing the cerebral cortex construction, neuronal migration is perhaps the most crucial as it ensures the timely formation of specific and selective neuronal circuits. Here, we review the main extrinsic and extrinsic factors involved in regulating neuronal migration in the cortex and describe some environmental factors interfering with their actions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticonvulsants / adverse effects
  • Cell Communication / physiology*
  • Cell Movement / physiology*
  • Cerebral Cortex / cytology*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology*
  • Humans
  • Interneurons / cytology
  • Interneurons / physiology
  • Neurogenesis / physiology
  • Neurons / cytology
  • Neurons / physiology*
  • Neurotransmitter Agents / metabolism

Substances

  • Anticonvulsants
  • Neurotransmitter Agents