Wrangling for microRNAs provokes much crosstalk

Genome Biol. 2011 Nov 21;12(11):132. doi: 10.1186/gb-2011-12-11-132.

Abstract

Levels of transcripts sharing microRNA response elements are co-regulated. These RNA-RNA interactions imply that combinations of microRNAs modulate cell-specific transcript networks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation*
  • Genome*
  • Humans
  • Mammals
  • MicroRNAs / genetics*
  • PTEN Phosphohydrolase / genetics
  • PTEN Phosphohydrolase / metabolism
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • RNA, Messenger / genetics*
  • Response Elements / genetics*
  • Retroelements / genetics

Substances

  • MicroRNAs
  • Protein Isoforms
  • RNA, Messenger
  • Retroelements
  • PTEN Phosphohydrolase
  • PTEN protein, human