Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites

J M Schaeffer; E G Frazier; A R Bergstrom; J M Williamson; J M Liesch; M A Goetz

doi:10.7164/antibiotics.43.1179

Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites

J Antibiot (Tokyo). 1990 Sep;43(9):1179-82. doi: 10.7164/antibiotics.43.1179.

Authors

J M Schaeffer¹, E G Frazier, A R Bergstrom, J M Williamson, J M Liesch, M A Goetz

Affiliation

¹ Department of Biochemical Parasitology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.

PMID: 2211380
DOI: 10.7164/antibiotics.43.1179

Abstract

Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.

MeSH terms

Animals
Antinematodal Agents / metabolism*
Antinematodal Agents / pharmacology
Benzoquinones / metabolism*
Benzoquinones / pharmacology
Binding Sites
Binding, Competitive
Caenorhabditis / drug effects*
Ivermectin / metabolism*
Molecular Structure
Receptors, Drug / metabolism*

Substances

Antinematodal Agents
Benzoquinones
Receptors, Drug
cochlioquinone A
Ivermectin