Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa

J Clin Microbiol. 2012 Feb;50(2):525-7. doi: 10.1128/JCM.05956-11. Epub 2011 Nov 23.

Abstract

This report documents emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in K. pneumoniae and Enterobacter cloacae in South Africa. NDM-1 producers have not been described in South Africa, and this is the first instance that KPC producers have been identified in Africa. The two patients infected with these carbapenemase-producing bacteria demised.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / enzymology*
  • Enterobacter cloacae / isolation & purification
  • Enterobacteriaceae Infections / microbiology*
  • Humans
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Microbial Sensitivity Tests
  • South Africa
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-lactamase KPC-2
  • beta-Lactamases
  • beta-lactamase NDM-1