Coagulation abnormalities in deceased donors are associated with unsuccessful human islet cell isolation

Diabetes Res Clin Pract. 2012 Mar;95(3):e45-8. doi: 10.1016/j.diabres.2011.10.044. Epub 2011 Nov 25.

Abstract

An equivalent islet number (EIN) greater than 300,000 is necessary for islet cell transplantation for a recipient who weighs about 60 kg. The aim of this study is to identify factors that affect isolation outcome. The most significant independent predictor for successful islet isolation from deceased donors was low international normalized ratio (INR).

MeSH terms

  • Blood Coagulation Disorders*
  • Cadaver
  • Cell Count
  • Humans
  • International Normalized Ratio*
  • Islets of Langerhans / pathology*
  • Islets of Langerhans Transplantation / standards*
  • Tissue Donors
  • Treatment Failure