Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Sara Frison; Elena Longhi; Martina Mantovani; Monica Mantia; Cinzia Tagliaferri; Daniela Di Giorgio; Mario Scalamogna; Francesca Poli

doi:10.1016/j.humimm.2011.11.004

Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Hum Immunol. 2012 Jan;73(1):67-9. doi: 10.1016/j.humimm.2011.11.004. Epub 2011 Nov 15.

Authors

Sara Frison¹, Elena Longhi, Martina Mantovani, Monica Mantia, Cinzia Tagliaferri, Daniela Di Giorgio, Mario Scalamogna, Francesca Poli

Affiliation

¹ Organ and Tissue Transplantation Immunology, Regenerative Medicine Department, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.

PMID: 22119882
DOI: 10.1016/j.humimm.2011.11.004

Abstract

We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.

MeSH terms

Alleles
Base Sequence
Genotyping Techniques / methods*
HLA-DRB1 Chains / genetics*
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Analysis, DNA / methods*
Sequence Homology, Nucleic Acid
White People / genetics

Substances

HLA-DRB1 Chains