Role of the MotB linker in the assembly and activation of the bacterial flagellar motor

Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1009-16. doi: 10.1107/S0907444911041102. Epub 2011 Nov 5.

Abstract

Bacterial flagella are driven by an ion influx through the peptidoglycan (PG)-tethered MotA/MotB stator. Stator precomplexes assemble in the membrane and remain inactive until they incorporate into the motor, upon which MotA/MotB changes conformation. The nature of this change and the mechanism of inhibition of the PG-binding and ion-conducting activities of the precomplexes are unknown. Here, the structural analysis of a series of N-terminally truncated MotB fragments is presented, the mechanism of inhibition by the linker is identified and the structural basis for the formation of the PG-binding-competent open-channel MotA/MotB conformation via a mechanism that entails linker unfolding and rotational displacement of MotB transmembrane helices is uncovered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Crystallography, X-Ray
  • Flagella / chemistry*
  • Flagella / metabolism
  • Helicobacter pylori / chemistry*
  • Helicobacter pylori / metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Binding
  • Protein Folding
  • Protein Structure, Quaternary
  • Protein Structure, Tertiary
  • Sequence Alignment

Substances

  • Bacterial Proteins
  • MotB protein, Bacteria