Increased serum Dickkopf-1 levels in drug-abusing psychotic patients

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Mar 30;36(2):239-44. doi: 10.1016/j.pnpbp.2011.11.006. Epub 2011 Nov 21.

Abstract

Background: Dickkopf-1 (DKK1) is an inhibitor of the canonical Wnt pathway, which is known to be impaired in both psychotic and neurodegenerative disorders. Here, we examined serum DKK1 levels as an indicator of ongoing neurodegeneration in psychotic patients, with or without a recent or current history of drug abuse.

Methods: We measured serum DKK1 levels by ELISA in 22 inpatients with psychosis and no history of drug abuse, 22 with psychosis and drug abuse, and 16 controls. We rated psychopathology using the following rating scales: the Positive and Negative Syndrome Scale (PANSS); the Clinical Global Impressions (CGI) severity scale; and the Global Assessment of Functioning (GAF) scale. Extrapyramidal motor symptoms were assessed by the Simpson-Angus Neurological Rating Scale (NRS).

Results: Inpatients with psychosis and comorbid substance abuse showed significantly higher serum DKK1 levels than inpatients with psychosis and no comorbid substance abuse or controls. Comorbid patients had earlier onset, longer duration of psychosis, and more severe extrapyramidal motor symptoms. However, we did not find any significant correlation between DKK1 levels and rating scale scores.

Conclusion: Psychosis led to elevated serum DKK1 levels, and substance abuse led to a further increase. Knowing that there is a correlation between brain and blood levels of DKK1, we speculate that the observed increase in DKK1 levels reflects drug-induced neurotoxicity in our patients.

MeSH terms

  • Adult
  • Basal Ganglia Diseases / blood
  • Basal Ganglia Diseases / complications
  • Case-Control Studies
  • Diagnosis, Dual (Psychiatry)
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales / statistics & numerical data
  • Psychotic Disorders / blood*
  • Psychotic Disorders / complications
  • Substance-Related Disorders / blood*
  • Substance-Related Disorders / complications

Substances

  • DKK1 protein, human
  • Intercellular Signaling Peptides and Proteins