Acremostrictin, a highly oxygenated metabolite from the marine fungus Acremonium strictum

Elin Julianti; Hana Oh; Kyoung Hwa Jang; Jae Kyun Lee; Sang Kook Lee; Dong-Chan Oh; Ki-Bong Oh; Jongheon Shin

doi:10.1021/np200707y

Acremostrictin, a highly oxygenated metabolite from the marine fungus Acremonium strictum

J Nat Prod. 2011 Dec 27;74(12):2592-4. doi: 10.1021/np200707y. Epub 2011 Dec 2.

Authors

Elin Julianti¹, Hana Oh, Kyoung Hwa Jang, Jae Kyun Lee, Sang Kook Lee, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin

Affiliation

¹ Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

PMID: 22136576
DOI: 10.1021/np200707y

Abstract

The novel natural product acremostrictin was isolated from the culture broth of Acremonium strictum, a marine fungus collected from a Choristida sponge off the coast of Korea. Structurally, acremostrictin is a tricyclic lactone of an unprecedented skeletal class based on combined spectroscopic and X-ray crystallographic analyses. The new compound exhibited weak antibacterial and moderate antioxidant activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acremonium / chemistry*
Animals
Antioxidants / metabolism
Biphenyl Compounds / pharmacology
Crystallography, X-Ray
Heterocyclic Compounds, Bridged-Ring / chemistry
Heterocyclic Compounds, Bridged-Ring / isolation & purification*
Korea
Marine Biology
Molecular Conformation
Molecular Structure
Picrates / pharmacology
Porifera / microbiology

Substances

Antioxidants
Biphenyl Compounds
Heterocyclic Compounds, Bridged-Ring
Picrates
acremostrictin
1,1-diphenyl-2-picrylhydrazyl